Single nucleotide substitutions (SNSs) are the major type of somatic variation in tumors 1,2. Even though the absolute majority of the point mutations are neutral 3, there are many examples of ...

Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated ...

Molecular testing, or molecular diagnostics, refers to a group of tests that look at the genetic material in a specimen. It can detect genetic risk factors for certain diseases or provide evidence of ...